CIDEC antibody (Internal Region)

Catalog No. ABIN6260841

Product Details anti-CIDEC Antibody

Target: CIDEC (Cell Death-Inducing DFFA-Like Effector C (CIDEC))

Binding Specificity: Internal Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CIDEC antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: CIDEC Antibody detects endogenous levels of total CIDEC.

Predicted Reactivity: Horse

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CIDEC, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for CIDEC

Target: CIDEC (Cell Death-Inducing DFFA-Like Effector C (CIDEC))

Alternative Name: CIDEC (CIDEC Products)

Synonyms: fsp27 antibody, cide-3 antibody, MGC89274 antibody, cidec antibody, MGC82483 antibody, CIDEC antibody, fd36c01 antibody, wu:fd36c01 antibody, zgc:153033 antibody, CIDE-3 antibody, CIDE3 antibody, FPLD5 antibody, FSP27 antibody, Fsp27 antibody, CIDE-C antibody, cell death inducing DFFA like effector c antibody, cell death inducing DFFA like effector c S homeolog antibody, cell death-inducing DFFA-like effector c antibody, Cell death activator CIDE-3 antibody, cidec antibody, cidec.S antibody, CIDEC antibody, Cidec antibody

Background:

Description: Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression.

Gene: CIDEC

Molecular Weight: 26 kDa

Gene ID: 63924

UniProt: Q96AQ7