CITED1 antibody (Internal Region)

Catalog No. ABIN6260846

Product Details anti-CITED1 Antibody

Target: CITED1 (Cbp/p300-Interacting Transactivator, with Glu/Asp-Rich Carboxy-terminal Domain, 1 (CITED1))

Binding Specificity: Internal Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CITED1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: CITED1 Antibody detects endogenous levels of total CITED1.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CITED1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for CITED1

Target: CITED1 (Cbp/p300-Interacting Transactivator, with Glu/Asp-Rich Carboxy-terminal Domain, 1 (CITED1))

Alternative Name: CITED1 (CITED1 Products)

Synonyms: cited1 antibody, fi05d05 antibody, CITED1 antibody, MSG1 antibody, AI316840 antibody, AU019144 antibody, Msg1 antibody, Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 antibody, Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 antibody, similar to Cbp/p300-interacting transactivator 1 (Melanocyte-specific protein 1) antibody, Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 antibody, cited1 antibody, CITED1 antibody, Cited1 antibody

Background:

Description: Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling, stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.

Gene: CITED1

Molecular Weight: 20 kDa

Gene ID: 4435

UniProt: Q99966