CRADD antibody (Internal Region)

Catalog No. ABIN6261016

Product Details anti-CRADD Antibody

Target: CRADD (CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRADD antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: CRADD Antibody detects endogenous levels of total CRADD.

Predicted Reactivity: Pig,Bovine,Sheep,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CRADD, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for CRADD

Target: CRADD (CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD))

Alternative Name: CRADD (CRADD Products)

Synonyms: cradd antibody, MGC89035 antibody, zgc:101717 antibody, CRADD antibody, DKFZp468A2219 antibody, LOC100226369 antibody, raidd antibody, MGC78788 antibody, MRT34 antibody, RAIDD antibody, CASP2 and RIPK1 domain containing adaptor with death domain antibody, CASP2 and RIPK1 domain containing adaptor with death, gene 1 antibody, CASP2 and RIPK1 domain containing adaptor with death, gene 2 S homeolog antibody, CRADD antibody, cradd.1 antibody, cradd antibody, cradd.2.S antibody, Cradd antibody

Background:

Description: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.

Gene: CRADD

Molecular Weight: 23kDa

Gene ID: 8738

UniProt: P78560

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity