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Cyclin C antibody (C-Term)

CCNC Reactivity: Human, Mouse, Rat WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6261144
  • Target See all Cyclin C (CCNC) Antibodies
    Cyclin C (CCNC)
    Binding Specificity
    • 18
    • 15
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 57
    • 24
    • 23
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 56
    • 1
    Rabbit
    Clonality
    • 57
    Polyclonal
    Conjugate
    • 25
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Cyclin C antibody is un-conjugated
    Application
    • 52
    • 26
    • 26
    • 21
    • 9
    • 8
    • 6
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    Cyclin C Antibody detects endogenous levels of total Cyclin C.
    Predicted Reactivity
    Bovine,Horse,Sheep,Rabbit,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human Cyclin C, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product CCNC Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    Cyclin C (CCNC)
    Alternative Name
    CCNC (CCNC Products)
    Synonyms
    CG1C_DROME antibody, CG7281 antibody, CYCC antibody, Cln3 antibody, Cyc-C antibody, DmcycC antibody, Dmel\\CG7281 antibody, SRB11 antibody, cycC antibody, cyclinC antibody, dTRAP33 antibody, fj11d06 antibody, wu:fj11d06 antibody, zgc:73078 antibody, Cyclin-C antibody, CycC antibody, AI451004 antibody, AU020987 antibody, CG1C antibody, Cyclin C antibody, cyclin C antibody, cyclin C L homeolog antibody, cyclin-C antibody, CycC antibody, ccnc antibody, CCNC antibody, Ccnc antibody, ccnc.L antibody, LOC5577815 antibody
    Background

    Description: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.

    Gene: CCNC

    Molecular Weight
    33 kDa
    Gene ID
    892
    UniProt
    P24863
    Pathways
    Cell Division Cycle, Regulation of Lipid Metabolism by PPARalpha
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