CYP4F2 antibody (N-Term)

Catalog No. ABIN6261173

Product Details anti-CYP4F2 Antibody

Target: CYP4F2 (Cytochrome P450, Family 4, Subfamily F, Polypeptide 2 (CYP4F2))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP4F2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Specificity: CYP4F2 Antibody detects endogenous levels of total CYP4F2.

Predicted Reactivity: Pig,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CYP4F2, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for CYP4F2

Target: CYP4F2 (Cytochrome P450, Family 4, Subfamily F, Polypeptide 2 (CYP4F2))

Alternative Name: CYP4F2 (CYP4F2 Products)

Synonyms: CPF2 antibody, MGC126966 antibody, cytochrome P450 family 4 subfamily F member 2 antibody, cytochrome P450, family 4, subfamily F, polypeptide 2 antibody, cytochrome P450 family 4 subfamily F member 2 L homeolog antibody, CYP4F2 antibody, cyp4f2.L antibody

Background:

Description: Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:19297519, PubMed:24138531). Also shows arachidonic acid omega-hydroxylase activity in kidney, by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), possibly influencing blood pressure control (PubMed:10660572, PubMed:17341693, PubMed:18574070). Also acts as a leukotriene-B4 omega-hydroxylase by mediating conversion of leukotriene-B4 (LTB4) to its omega-hydroxylated metabolite 20-hydroxyleukotriene-B4 (20-OH LTB4) (PubMed:8026587, PubMed:9799565).

Gene: CYP4F2

Molecular Weight: 60kDa

Gene ID: 8529

UniProt: P78329

Pathways: Monocarboxylic Acid Catabolic Process