DNAJB2 antibody (Internal Region)

Catalog No. ABIN6261330

Product Details anti-DNAJB2 Antibody

Target: DNAJB2 (DnaJ (Hsp40) Homolog, Subfamily B, Member 2 (DNAJB2))

Binding Specificity: Internal Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNAJB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: DNAJB2 Antibody detects endogenous levels of total DNAJB2.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human DNAJB2, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for DNAJB2

Target: DNAJB2 (DnaJ (Hsp40) Homolog, Subfamily B, Member 2 (DNAJB2))

Alternative Name: DNAJB2 (DNAJB2 Products)

Synonyms: MGC78895 antibody, DSMA5 antibody, HSJ-1 antibody, HSJ1 antibody, HSPF3 antibody, 2700059H22Rik antibody, Dnajb10 antibody, Hsj1 antibody, mDj8 antibody, DnaJ heat shock protein family (Hsp40) member B2 L homeolog antibody, DnaJ heat shock protein family (Hsp40) member B2 antibody, dnajb2.L antibody, DNAJB2 antibody, dnajb2 antibody, Dnajb2 antibody

Background:

Description: Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:7957263, PubMed:22219199). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278).

Gene: DNAJB2

Molecular Weight: 36 kDa

Gene ID: 3300

UniProt: P25686