EIF3B antibody

Catalog No. ABIN6261481

Product Details anti-EIF3B Antibody

Target: EIF3B (Eukaryotic Translation Initiation Factor 3, Subunit B (EIF3B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EIF3B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificity: EIF3B Antibody detects endogenous levels of total EIF3B

Cross-Reactivity: Human, Mouse (Murine)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human EIF3B

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000 IHC 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C.Stable for 12 months from date of receipt

Expiry Date: 12 months

Target Details for EIF3B

Target: EIF3B (Eukaryotic Translation Initiation Factor 3, Subunit B (EIF3B))

Alternative Name: EIF3B (EIF3B Products)

Synonyms: EIF3-ETA antibody, EIF3-P110 antibody, EIF3-P116 antibody, EIF3S9 antibody, PRT1 antibody, AL033316 antibody, AL033334 antibody, AL033369 antibody, AW208965 antibody, D5Wsu45e antibody, Eif3s9 antibody, eif3-eta antibody, eif3-p110 antibody, eif3-p116 antibody, eif3s9 antibody, prt1 antibody, ATEIF3B-2 antibody, EIF3B antibody, EUKARYOTIC TRANSLATION INITIATION FACTOR 3B antibody, F18A17.30 antibody, F18A17_30 antibody, eukaryotic translation initiation factor 3B-2 antibody, DDBDRAFT_0218512 antibody, DDBDRAFT_0233929 antibody, DDB_0218512 antibody, DDB_0233929 antibody, eIF-3-eta antibody, eif3b antibody, wu:fc17c01 antibody, GB10123 antibody, eIF3b antibody, AO090005000892 antibody, CaO19.6584 antibody, eIF3 p90 antibody, eukaryotic translation initiation factor 3 subunit B antibody, eukaryotic translation initiation factor 3, subunit B antibody, eukaryotic translation initiation factor 3B-2 antibody, eukaryotic initiation factor antibody, RNA recognition motif-containing protein RRM antibody, eukaryotic translation initiation factor 3b antibody, eukaryotic translation initiation factor 3 subunit B L homeolog antibody, eukaryotic translation initiation factor 3, subunit Ba antibody, eukaryotic translation initiation factor 3 subunit 9 antibody, translation initiation factor eIF-3 subunit 9 antibody, Eukaryotic translation initiation factor 3 subunit B antibody, translation initiation factor eIF3 subunit b antibody, EIF3B antibody, Eif3b antibody, eif3b antibody, EIF3B-2 antibody, eIF3s9 antibody, eif3B antibody, eif3b.L antibody, eif3ba antibody, LOC410100 antibody, eIF3-S9 antibody, AOR_1_1564174 antibody, VDBG_02490 antibody, PGTG_13070 antibody, Tsp_02250 antibody, eif-3.B antibody, PRT1 antibody

Background:

Description: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:9388245, PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:9388245, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene: EIF3B

Molecular Weight: 116 kDa

Gene ID: 8662

UniProt: P55884

Pathways: Ribonucleoprotein Complex Subunit Organization