ERAP1 antibody (Internal Region)

Catalog No. ABIN6261584

Product Details anti-ERAP1 Antibody

Target: ERAP1 (Endoplasmic Reticulum Aminopeptidase 1 (ERAP1))

Binding Specificity: Internal Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERAP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: ERAP1 Antibody detects endogenous levels of total ERAP1.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ERAP1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for ERAP1

Target: ERAP1 (Endoplasmic Reticulum Aminopeptidase 1 (ERAP1))

Alternative Name: ERAP1 (ERAP1 Products)

Synonyms: MGC166160 antibody, DKFZp469C044 antibody, ARTS-1 antibody, A-LAP antibody, ALAP antibody, APPILS antibody, ARTS1 antibody, ERAAP antibody, ERAAP1 antibody, PILS-AP antibody, PILSAP antibody, Arts1 antibody, PILSA antibody, Appils antibody, endoplasmic reticulum aminopeptidase 1 antibody, endoplasmic reticulum aminopeptidase 1b antibody, ERAP1 antibody, erap1 antibody, erap1b antibody, Erap1 antibody

Background:

Description: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.

Gene: ERAP1

Molecular Weight: 107 kDa

Gene ID: 51752

UniProt: Q9NZ08