FAF2 antibody (Internal Region)

Catalog No. ABIN6261659

Product Details anti-FAF2 Antibody

Target: FAF2 (Fas Associated Factor Family Member 2 (FAF2))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAF2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: FAF2 Antibody detects endogenous levels of total FAF2.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human FAF2, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for FAF2

Target: FAF2 (Fas Associated Factor Family Member 2 (FAF2))

Alternative Name: FAF2 (FAF2 Products)

Synonyms: FAF2 antibody, UBXD8 antibody, ETEA antibody, UBXN3B antibody, 2210404D11Rik antibody, AI462440 antibody, Ubxd8 antibody, mKIAA0887 antibody, 2210404d11rik antibody, RGD1306577 antibody, UBX8 antibody, etea antibody, ubxd8 antibody, ubxn3b antibody, Fas associated factor family member 2 antibody, Fas associated factor family member 2 S homeolog antibody, FAF2 antibody, Faf2 antibody, faf2.S antibody

Background:

Description: Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis (PubMed:23297223).

Gene: FAF2

Molecular Weight: 53 kDa

Gene ID: 23197

UniProt: Q96CS3