GAS8 antibody (Internal Region)

Catalog No. ABIN6261889

Product Details anti-GAS8 Antibody

Target: GAS8 (Growth Arrest-Specific 8 (GAS8))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GAS8 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB)

Specificity: GAS8 Antibody detects endogenous levels of total GAS8.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human GAS8, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for GAS8

Target: GAS8 (Growth Arrest-Specific 8 (GAS8))

Alternative Name: GAS8 (GAS8 Products)

Synonyms: CG14271 antibody, Dmel\\CG14271 antibody, zgc:66271 antibody, wu:fb93e12 antibody, MGC114774 antibody, Gas11 antibody, GAS11 antibody, Growth arrest specific protein 8 antibody, growth arrest-specific 8 antibody, growth arrest specific 8 antibody, growth arrest specific 8 S homeolog antibody, Gas8 antibody, gas8 antibody, GAS8 antibody, gas8.S antibody

Background:

Description: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning (PubMed:26387594, PubMed:27120127, PubMed:27472056). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner (By similarity).

Gene: GAS8

Molecular Weight: 56 kDa

Gene ID: 2622

UniProt: O95995