HECW1 antibody (Internal Region)
-
- Target See all HECW1 Antibodies
- HECW1 (HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 1 (HECW1))
- Binding Specificity
- Internal Region
- Reactivity
- Human, Rat
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This HECW1 antibody is un-conjugated
- Application
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
- Specificity
- HECW1 Antibody detects endogenous levels of total HECW1.
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human HECW1, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product HECW1 Primary Antibody
-
-
- Application Notes
- WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
-
- Target
- HECW1 (HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 1 (HECW1))
- Alternative Name
- HECW1 (HECW1 Products)
- Synonyms
- NEDL1 antibody, 9330116H24Rik antibody, AV273951 antibody, E130207I19Rik antibody, Nedl1 antibody, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 antibody, HECW1 antibody, Hecw1 antibody
- Background
-
Description: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.
Gene: HECW1
- Molecular Weight
- 180kDa
- Gene ID
- 23072
- UniProt
- Q76N89
-