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IFNAR1 antibody (Internal Region)

IFNAR1 Reactivity: Human, Mouse, Rat WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6262471
  • Target See all IFNAR1 Antibodies
    IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))
    Binding Specificity
    • 22
    • 16
    • 13
    • 9
    • 7
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 88
    • 29
    • 20
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 81
    • 17
    • 1
    Rabbit
    Clonality
    • 72
    • 26
    • 1
    Polyclonal
    Conjugate
    • 50
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This IFNAR1 antibody is un-conjugated
    Application
    • 47
    • 27
    • 27
    • 26
    • 24
    • 24
    • 10
    • 9
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Specificity
    IFNAR1 Antibody detects endogenous levels of total IFNAR1.
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human IFNAR1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product IFNAR1 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))
    Alternative Name
    IFNAR1 (IFNAR1 Products)
    Synonyms
    ifnar1 antibody, IFNAR1 antibody, CD118 antibody, Ifar antibody, Ifnar antibody, Ifrc antibody, Infar antibody, AVP antibody, IFN-alpha-REC antibody, IFNAR antibody, IFNBR antibody, IFRC antibody, IFN-R-1 antibody, interferon alpha and beta receptor subunit 1 antibody, interferon-alpha/beta receptor alpha chain-like antibody, interferon (alpha and beta) receptor 1 antibody, interferon alpha/beta receptor 1 antibody, IFNAR1 antibody, ifnar1 antibody, Ifnar1 antibody, LOC609830 antibody
    Background

    Description: Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).

    Gene: IFNAR1

    Molecular Weight
    63kDa
    Gene ID
    3454
    UniProt
    P17181
    Pathways
    JAK-STAT Signaling, Hepatitis C
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