IL31RA antibody (Internal Region)

Catalog No. ABIN6262566

Product Details anti-IL31RA Antibody

Target: IL31RA (Interleukin 31 Receptor A (IL31RA))

Binding Specificity: Internal Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL31RA antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: IL31R Antibody detects endogenous levels of total IL31R.

Predicted Reactivity: Pig,Bovine,Sheep,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human IL31R, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for IL31RA

Target: IL31RA (Interleukin 31 Receptor A (IL31RA))

Alternative Name: IL31RA (IL31RA Products)

Synonyms: IL31RA antibody, CRL antibody, CRL3 antibody, GLM-R antibody, GLMR antibody, GPL antibody, IL-31RA antibody, PLCA2 antibody, PRO21384 antibody, hGLM-R antibody, Glmr antibody, NR10 antibody, interleukin 31 receptor A antibody, IL31RA antibody, Il31ra antibody

Background:

Description: Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 (PubMed:11877449, PubMed:14504285, PubMed:15627637, PubMed:15194700). May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity).

Gene: IL31RA

Molecular Weight: 83 kDa

Gene ID: 133396

UniProt: Q8NI17