KIDINS220 antibody (Internal Region)

Catalog No. ABIN6262800

Product Details anti-KIDINS220 Antibody

Target: KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))

Binding Specificity: Internal Region

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIDINS220 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: KIDINS220 Antibody detects endogenous levels of total KIDINS220.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human KIDINS220, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for KIDINS220

Target: KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))

Alternative Name: KIDINS220 (KIDINS220 Products)

Synonyms: ARMS antibody, fj35h03 antibody, kidins220 antibody, zgc:63531 antibody, dZ119J18.2 antibody, wu:fj35h03 antibody, 3110039L19Rik antibody, AI194387 antibody, AI316525 antibody, C330002I19Rik antibody, mKIAA1250 antibody, kinase D interacting substrate 220 antibody, kinase D-interacting substrate 220 antibody, kinase D-interacting substrate 220b antibody, kinase D-interacting substrate 220kDa antibody, KIDINS220 antibody, Kidins220 antibody, kidins220b antibody

Background:

Description: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

Gene: KIDINS220

Molecular Weight: 186-197 kDa

Gene ID: 57498

UniProt: Q9ULH0