Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

MPHOSPH8 antibody (Internal Region)

MPHOSPH8 Reactivity: Human, Mouse, Rat WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6263338
  • Target See all MPHOSPH8 Antibodies
    MPHOSPH8 (M-Phase phosphoprotein 8 (MPHOSPH8))
    Binding Specificity
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 13
    • 9
    • 9
    • 1
    Human, Mouse, Rat
    Host
    • 12
    • 2
    Rabbit
    Clonality
    • 13
    • 1
    Polyclonal
    Conjugate
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MPHOSPH8 antibody is un-conjugated
    Application
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Specificity
    MPHOSPH8 Antibody detects endogenous levels of total MPHOSPH8.
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human MPHOSPH8, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product MPHOSPH8 Primary Antibody
  • Application Notes
    WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    MPHOSPH8 (M-Phase phosphoprotein 8 (MPHOSPH8))
    Alternative Name
    MPHOSPH8 (MPHOSPH8 Products)
    Synonyms
    HSMPP8 antibody, TWA3 antibody, mpp8 antibody, 1500035L22Rik antibody, 4930548G07Rik antibody, AU040635 antibody, Ab2-008 antibody, RGD1305133 antibody, M-phase phosphoprotein 8 antibody, MPHOSPH8 antibody, Mphosph8 antibody
    Background

    Description: Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites, these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592).

    Gene: MPHOSPH8

    Molecular Weight
    97 kDa
    Gene ID
    54737
    UniProt
    Q99549
You are here:
Support