NFKBIZ antibody (Internal Region)
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- Target See all NFKBIZ Antibodies
- NFKBIZ (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, zeta (NFKBIZ))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NFKBIZ antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Specificity
- NFKBIZ Antibody detects endogenous levels of total NFKBIZ.
- Predicted Reactivity
- Bovine,Horse,Sheep,Rabbit
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human NFKBIZ, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product NFKBIZ Primary Antibody
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- Application Notes
- WB 1:500-1:2000, IHC 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- NFKBIZ (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, zeta (NFKBIZ))
- Alternative Name
- NFKBIZ (NFKBIZ Products)
- Synonyms
- RGD1310834 antibody, NFKBIZ antibody, MAIL antibody, AA408868 antibody, INAP antibody, Mail antibody, IKBZ antibody, NFKB inhibitor zeta antibody, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta antibody, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta antibody, Nfkbiz antibody, NFKBIZ antibody, nfkbiz antibody
- Background
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Description: Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity).
Gene: NFKBIZ
- Molecular Weight
- 64 kDa
- Gene ID
- 64332
- UniProt
- Q9BYH8
- Pathways
- NF-kappaB Signaling
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