OCRL antibody (C-Term)

Catalog No. ABIN6263797

Product Details anti-OCRL Antibody

Target: OCRL (Oculocerebrorenal Syndrome of Lowe (OCRL))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OCRL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: OCRL Antibody detects endogenous levels of total OCRL.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human OCRL, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for OCRL

Target: OCRL (Oculocerebrorenal Syndrome of Lowe (OCRL))

Alternative Name: OCRL (OCRL Products)

Synonyms: OCRL antibody, wu:fi09g03 antibody, zgc:152864 antibody, locr antibody, nphl2 antibody, ocrl1 antibody, inpp5f antibody, INPP5F antibody, LOCR antibody, NPHL2 antibody, OCRL-1 antibody, OCRL1 antibody, 9530014D17Rik antibody, BB143339 antibody, OCRL, inositol polyphosphate-5-phosphatase antibody, phosphatidylinositol polyphosphate 5-phosphatase antibody, oculocerebrorenal syndrome of Lowe antibody, Ocrl antibody, NAEGRDRAFT_58601 antibody, OCRL antibody, ocrl antibody

Background:

Description: Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate (PubMed:25869668, PubMed:7761412, PubMed:9430698). May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Involved in primary cilia assembly (PubMed:22228094, PubMed:22543976).

Gene: OCRL

Molecular Weight: 104 kDa

Gene ID: 4952

UniProt: Q01968

Pathways: Inositol Metabolic Process