OMA1 antibody (Internal Region)

Catalog No. ABIN6263821

Product Details anti-OMA1 Antibody

Target: OMA1 (OMA1 Zinc Metallopeptidase Homolog (OMA1))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OMA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: OMA1 Antibody detects endogenous levels of total OMA1.

Predicted Reactivity: Zebrafish,Bovine,Sheep,Rabbit

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human OMA1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for OMA1

Target: OMA1 (OMA1 Zinc Metallopeptidase Homolog (OMA1))

Alternative Name: OMA1 (OMA1 Products)

Synonyms: 2010001O09Rik antibody, DAB1 antibody, MPRP-1 antibody, YKR087C antibody, ZMPOMA1 antibody, peptidase antibody, RGD1304821 antibody, oma1 antibody, OMA1 zinc metallopeptidase antibody, si:ch73-215a11.1 antibody, olfactory receptor 4K2 antibody, OMA1 antibody, Oma1 antibody, si:ch73-215a11.1 antibody, LOC531304 antibody

Background:

Description: Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions.

Gene: OMA1

Molecular Weight: 60 kDa

Gene ID: 115209

UniProt: Q96E52