PACS2 antibody (Internal Region)

Catalog No. ABIN6264008

Product Details anti-PACS2 Antibody

Target: PACS2 (phosphofurin Acidic Cluster Sorting Protein 2 (PACS2))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PACS2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: PACS2 Antibody detects endogenous levels of total PACS2.

Predicted Reactivity: Pig,Bovine,Horse,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PACS2, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for PACS2

Target: PACS2 (phosphofurin Acidic Cluster Sorting Protein 2 (PACS2))

Alternative Name: PACS2 (PACS2 Products)

Synonyms: PACS-2 antibody, PACS1L antibody, 6720425G15Rik antibody, AW208651 antibody, AW489976 antibody, E230011J22 antibody, Pacs1l antibody, mKIAA0602 antibody, phosphofurin acidic cluster sorting protein 2 antibody, PACS2 antibody, Pacs2 antibody

Background:

Description: Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.

Gene: PACS2

Molecular Weight: 116 kDa

Gene ID: 23241

UniProt: Q86VP3