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PLA2G2A antibody (Internal Region)

PLA2G2A Reactivity: Human, Rat, Mouse ELISA, WB, IHC, ICC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6264274
  • Target See all PLA2G2A Antibodies
    PLA2G2A (Phospholipase A2, Group IIA (Platelets, Synovial Fluid) (PLA2G2A))
    Binding Specificity
    • 9
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    Human, Rat, Mouse
    Host
    • 31
    • 5
    • 2
    • 1
    Rabbit
    Clonality
    • 32
    • 7
    Polyclonal
    Conjugate
    • 20
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PLA2G2A antibody is un-conjugated
    Application
    • 23
    • 20
    • 11
    • 7
    • 2
    • 2
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificity
    PLA2G2A Antibody detects endogenous levels of total PLA2G2A.
    Predicted Reactivity
    Pig,Horse,Rabbit
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human PLA2G2A, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product PLA2G2A Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    PLA2G2A (Phospholipase A2, Group IIA (Platelets, Synovial Fluid) (PLA2G2A))
    Alternative Name
    PLA2G2A (PLA2G2A Products)
    Synonyms
    MOM1 antibody, PLA2 antibody, PLA2B antibody, PLA2L antibody, PLA2S antibody, PLAS1 antibody, sPLA2 antibody, EF antibody, Mom1 antibody, Pla2 antibody, sPla2-IIA antibody, phospholipase A2 group IIA antibody, phospholipase A2, group IIA (platelets, synovial fluid) antibody, PLA2G2A antibody, Pla2g2a antibody
    Background

    Description: Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:2925633). Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536).

    Gene: PLA2G2A

    Molecular Weight
    16kDa
    Gene ID
    5320
    UniProt
    P14555
    Pathways
    Stem Cell Maintenance, Inositol Metabolic Process
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