Presenilin 2 antibody (Internal Region)

Catalog No. ABIN6264464

Product Details anti-Presenilin 2 Antibody

Target: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Binding Specificity: Internal Region

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Presenilin 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: Presenilin 2 Antibody detects endogenous levels of total Presenilin 2.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Presenilin 2, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for Presenilin 2

Target: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Alternative Name: PSEN2 (PSEN2 Products)

Synonyms: AD3L antibody, AD4 antibody, CMD1V antibody, PS2 antibody, STM2 antibody, ALG-3 antibody, Ad4h antibody, Alg3 antibody, PS-2 antibody, Psnl2 antibody, pre2 antibody, zf-PS2 antibody, PSNL2 antibody, PSEN2 antibody, ad4 antibody, ps2 antibody, ad3l antibody, stm2 antibody, Ps2 antibody, presenilin 2 antibody, presenilin 2 S homeolog antibody, presenilin 2 (Alzheimer disease 4) antibody, trefoil factor 1 antibody, PSEN2 antibody, Psen2 antibody, psen2 antibody, psen2.S antibody, Tff1 antibody

Background:

Description: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.

Gene: PSEN2

Molecular Weight: 50kDa

Gene ID: 5664

UniProt: P49810

Pathways: Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway