PSMC4 antibody (C-Term)

Catalog No. ABIN6264481

Product Details anti-PSMC4 Antibody

Target: PSMC4 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMC4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificity: PSMC4 Antibody detects endogenous levels of total PSMC4.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PSMC4, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for PSMC4

Target: PSMC4 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4))

Alternative Name: PSMC4 (PSMC4 Products)

Synonyms: NCU02260.1 antibody, AO090003000692 antibody, DDBDRAFT_0188209 antibody, DDBDRAFT_0191435 antibody, DDB_0188209 antibody, DDB_0191435 antibody, MIP224 antibody, RPT3 antibody, S6 antibody, TBP-7 antibody, TBP7 antibody, CIP21 antibody, Tbp7 antibody, 26S protease regulatory subunit 6B antibody, regulatory particle, ATPase-like-3 antibody, 26S proteasome regulatory subunit 6B antibody, proteasome 26S subunit, ATPase 4 antibody, proteasome (prosome, macropain) 26S subunit, ATPase, 4 antibody, LOC732870 antibody, rpt-3 antibody, ATEG_04674 antibody, LELG_01296 antibody, HCAG_00039 antibody, LOC5568998 antibody, GL50803_7950 antibody, EDI_044950 antibody, AOR_1_1218154 antibody, PTRG_03339 antibody, psmC4 antibody, prs6b antibody, LOC100381342 antibody, psmc4 antibody, PSMC4 antibody, Psmc4 antibody

Background:

Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

Gene: PSMC4

Molecular Weight: 47kDa

Gene ID: 5704

UniProt: P43686

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway