PSMC6 antibody (Internal Region)

Catalog No. ABIN6264483

Product Details anti-PSMC6 Antibody

Target: PSMC6 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 6 (PSMC6))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMC6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificity: PSMC6 Antibody detects endogenous levels of total PSMC6.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PSMC6, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for PSMC6

Target: PSMC6 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 6 (PSMC6))

Alternative Name: PSMC6 (PSMC6 Products)

Synonyms: DDBDRAFT_0186051 antibody, DDBDRAFT_0232968 antibody, DDB_0186051 antibody, DDB_0232968 antibody, fb20g04 antibody, wu:fb20g04 antibody, wu:fc85c10 antibody, cadp44 antibody, sug2 antibody, PSMC6 antibody, psmc6-a antibody, NV13405 antibody, CADP44 antibody, P44 antibody, SUG2 antibody, p42 antibody, 2300001E01Rik antibody, AI451058 antibody, 26S protease regulatory subunit S10B antibody, 26S proteasome regulatory subunit 10B antibody, proteasome 26S subunit, ATPase 6 antibody, proteasome 26S subunit, ATPase 6 L homeolog antibody, 26S protease regulatory subunit 10B antibody, proteasome 26S subunit, ATPase 6 S homeolog antibody, proteasome (prosome, macropain) 26S subunit, ATPase, 6 antibody, ATEG_02903 antibody, HCAG_04181 antibody, LOC5565051 antibody, EDI_289460 antibody, CpipJ_CPIJ003334 antibody, EHI_194070 antibody, PTRG_02716 antibody, BDBG_01801 antibody, psmC6 antibody, MCYG_07206 antibody, PITG_00229 antibody, VDBG_04729 antibody, MGYG_04704 antibody, TERG_01608 antibody, DICPUDRAFT_97252 antibody, Tsp_02519 antibody, prs10 antibody, LOC100282100 antibody, Psmc6 antibody, psmc6 antibody, psmc6.L antibody, PSMC6 antibody, LOC693577 antibody, psmc6.S antibody, LOC100117671 antibody

Background:

Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

Gene: PSMC6

Molecular Weight: 44kDa

Gene ID: 5706

UniProt: P62333

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway