Retinoic Acid Receptor gamma antibody

Catalog No. ABIN6264704

Product Details anti-Retinoic Acid Receptor gamma Antibody

Target: Retinoic Acid Receptor gamma (RARG) (Retinoic Acid Receptor, gamma (RARG))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Retinoic Acid Receptor gamma antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: Retinoic Acid Receptor / Antibody detects endogenous levels of Retinoic Acid Receptor /

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Retinoic Acid Receptor /

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C.Stable for 12 months from date of receipt

Expiry Date: 12 months

Target Details for Retinoic Acid Receptor gamma

Target: Retinoic Acid Receptor gamma (RARG) (Retinoic Acid Receptor, gamma (RARG))

Alternative Name: Retinoic Acid Receptor (RARG Products)

Synonyms: NR1B3 antibody, RARC antibody, AI385767 antibody, Nr1b3 antibody, RARD antibody, RARgamma2 antibody, RARG antibody, etID309710.23 antibody, etID33387.23 antibody, rarg antibody, rarg2 antibody, wu:fb01e02 antibody, wu:fb01f03 antibody, wu:fc35a09 antibody, nr1b3 antibody, RARgamma-B antibody, retinoic acid receptor gamma antibody, retinoic acid receptor, gamma antibody, retinoic acid receptor gamma a antibody, retinoic acid receptor gamma S homeolog antibody, retinoic acid receptor, gamma b antibody, RARG antibody, Rarg antibody, rarga antibody, rarg.S antibody, rargb antibody

Background:

Description: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).

Gene: RARA

Molecular Weight: 50kDa

Gene ID: 5914

UniProt: P10276, P10826

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Cell Size