Retinoic Acid Receptor beta antibody (Internal Region)

Catalog No. ABIN6264705

Product Details anti-Retinoic Acid Receptor beta Antibody

Target: Retinoic Acid Receptor beta (RARB) (Retinoic Acid Receptor, beta (RARB))

Binding Specificity: Internal Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Retinoic Acid Receptor beta antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: Retinoic Acid Receptor beta Antibody detects endogenous levels of total Retinoic Acid Receptor beta.

Predicted Reactivity: Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Retinoic Acid Receptor beta, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for Retinoic Acid Receptor beta

Target: Retinoic Acid Receptor beta (RARB) (Retinoic Acid Receptor, beta (RARB))

Alternative Name: RARB (RARB Products)

Synonyms: RARB antibody, nRARs antibody, HAP antibody, NR1B2 antibody, RRB2 antibody, A830025K23 antibody, Hap antibody, Nr1b2 antibody, RARbeta2 antibody, RARBETA antibody, retinoic acid receptor beta antibody, retinoic acid receptor, beta antibody, RARB antibody, Rarb antibody

Background:

Description: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.

Gene: RARB

Molecular Weight: 50kDa

Gene ID: 5915

UniProt: P10826

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway