RQCD1 antibody (Internal Region)

Catalog No. ABIN6264862

Product Details anti-RQCD1 Antibody

Target: RQCD1 (RCD1 Required For Cell Differentiation1 Homolog (RQCD1))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RQCD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: RQCD1 Antibody detects endogenous levels of total RQCD1.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human RQCD1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for RQCD1

Target: RQCD1 (RCD1 Required For Cell Differentiation1 Homolog (RQCD1))

Alternative Name: CNOT9 (RQCD1 Products)

Synonyms: 2610007F23Rik antibody, AI593551 antibody, Fl10 antibody, CNOT9 antibody, CT129 antibody, RCD-1 antibody, RCD1 antibody, wu:fb52b11 antibody, wu:fb74e08 antibody, zgc:85618 antibody, CCR4-NOT transcription complex, subunit 9 antibody, CCR4-NOT transcription complex subunit 9 antibody, Cnot9 antibody, CNOT9 antibody, cnot9 antibody

Background:

Description: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.

Gene: CNOT9

Molecular Weight: 34-40 kDa

Gene ID: 9125

UniProt: Q92600

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling