RYR2 antibody (Internal Region)

Catalog No. ABIN6264892

Product Details anti-RYR2 Antibody

Target: RYR2 (Ryanodine Receptor 2 (Cardiac) (RYR2))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RYR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: RYR2 Antibody detects endogenous levels of total RYR2.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human RYR2, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol. .

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for RYR2

Target: RYR2 (Ryanodine Receptor 2 (Cardiac) (RYR2))

Alternative Name: RYR2 (RYR2 Products)

Synonyms: RYR2 antibody, ARVC2 antibody, ARVD2 antibody, RYR-2 antibody, RyR antibody, VTSIP antibody, 9330127I20Rik antibody, ryanodine receptor 2 antibody, ryanodine receptor 2, cardiac antibody, RYR2 antibody, Ryr2 antibody

Background:

Description: Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca2+ levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.

Gene: RYR2

Molecular Weight: 564 kDa

Gene ID: 6262

UniProt: Q92736

Pathways: Myometrial Relaxation and Contraction