SCG5 antibody (Internal Region)

Catalog No. ABIN6264938

Product Details anti-SCG5 Antibody

Target: SCG5 (Secretogranin V (7B2 Protein) (SCG5))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCG5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: SCG5 Antibody detects endogenous levels of total SCG5.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human SCG5, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for SCG5

Target: SCG5 (Secretogranin V (7B2 Protein) (SCG5))

Alternative Name: SCG5 (SCG5 Products)

Synonyms: zgc:73132 antibody, sgne1 antibody, MGC145087 antibody, 7B2 antibody, AI325031 antibody, Sgne-1 antibody, Sgne1 antibody, P7B2 antibody, SGNE1 antibody, SgV antibody, secretogranin V antibody, scg5 antibody, SCG5 antibody, Scg5 antibody

Background:

Description: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.

Gene: SCG5

Molecular Weight: 24 kDa

Gene ID: 6447

UniProt: P05408