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SMAD6 antibody (Internal Region)

SMAD6 Reactivity: Human, Mouse WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6265164
  • Target See all SMAD6 Antibodies
    SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))
    Binding Specificity
    • 15
    • 9
    • 9
    • 8
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 52
    • 28
    • 12
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    Human, Mouse
    Host
    • 54
    • 14
    Rabbit
    Clonality
    • 56
    • 12
    Polyclonal
    Conjugate
    • 41
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SMAD6 antibody is un-conjugated
    Application
    • 59
    • 39
    • 15
    • 12
    • 6
    • 3
    • 3
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Specificity
    SMAD6 Antibody detects endogenous levels of total SMAD6.
    Predicted Reactivity
    Pig,Bovine,Horse,Sheep,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human SMAD6, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product SMAD6 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))
    Alternative Name
    SMAD6 (SMAD6 Products)
    Synonyms
    madh6 antibody, madh7 antibody, Xsmad6 antibody, hst17432 antibody, AOVD2 antibody, HsT17432 antibody, MADH6 antibody, MADH7 antibody, Madh6 antibody, b2b390Clo antibody, Smad6-like antibody, smad6 antibody, wu:fb22g05 antibody, SMAD family member 6 antibody, SMAD family member 6a antibody, smad6 antibody, SMAD6 antibody, Smad6 antibody, smad6a antibody
    Background

    Description: Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.

    Gene: SMAD6

    Molecular Weight
    53 kDa
    Gene ID
    4091
    UniProt
    O43541
    Pathways
    Chromatin Binding
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