SMYD2A antibody (Internal Region)

Catalog No. ABIN6265198

Product Details anti-SMYD2A Antibody

Target: SMYD2A (SET and MYND Domain Containing 2a (SMYD2A))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMYD2A antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: SMYD2 Antibody detects endogenous levels of total SMYD2.

Predicted Reactivity: Pig,Bovine,Horse,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human SMYD2, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for SMYD2A

Target: SMYD2A (SET and MYND Domain Containing 2a (SMYD2A))

Alternative Name: SMYD2 (SMYD2A Products)

Synonyms: HSKM-B antibody, KMT3C antibody, ZMYND14 antibody, 1110020E07Rik antibody, 4930402C15 antibody, Zmynd14 antibody, smyd2-a antibody, im:7146196 antibody, smyd2 antibody, wu:fc02f02 antibody, zgc:110553 antibody, si:dkey-121j17.3 antibody, zgc:136609 antibody, SET and MYND domain containing 2 antibody, SET and MYND domain containing 2 S homeolog antibody, SET and MYND domain containing 2a antibody, SET and MYND domain containing 2b antibody, SMYD2 antibody, Smyd2 antibody, smyd2.S antibody, smyd2a antibody, smyd2b antibody

Background:

Description: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.

Gene: SMYD2

Molecular Weight: 49 kDa

Gene ID: 56950

UniProt: Q9NRG4