UIMC1 antibody (Internal Region)
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- Target See all UIMC1 Antibodies
- UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
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Binding Specificity
- Internal Region
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This UIMC1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Specificity
- UIMC1 Antibody detects endogenous levels of total UIMC1.
- Predicted Reactivity
- Horse,Rabbit,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human UIMC1, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product UIMC1 Primary Antibody
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- Application Notes
- WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
- Alternative Name
- UIMC1 (UIMC1 Products)
- Synonyms
- UIMC1 antibody, RAP80 antibody, X2HRIP110 antibody, 9430016E08Rik antibody, D330018D10Rik antibody, D630032M02Rik antibody, RIP110 antibody, Rxrip110 antibody, RGD1307009 antibody, ubiquitin interaction motif containing 1 antibody, UIMC1 antibody, Uimc1 antibody
- Background
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Description: Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref. 37). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B, the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
Gene: UIMC1
- Molecular Weight
- 80 kDa
- Gene ID
- 51720
- UniProt
- Q96RL1
- Pathways
- DNA Damage Repair, Nuclear Hormone Receptor Binding, Positive Regulation of Response to DNA Damage Stimulus
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