VPS33B antibody

Catalog No. ABIN6265997

Product Details anti-VPS33B Antibody

Target: VPS33B (Vacuolar Protein Sorting-Associated Protein 33B (VPS33B))

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VPS33B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: VPS33B antibody detects endogenous levels of VPS33B.

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus), Zebrafish (Danio rerio)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human VPS33B.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C.Stable for 12 months from date of receipt

Expiry Date: 12 months

Target Details for VPS33B

Target: VPS33B (Vacuolar Protein Sorting-Associated Protein 33B (VPS33B))

Alternative Name: VPS33B (VPS33B Products)

Synonyms: CG5127 antibody, Dmel\\CG5127 antibody, VPS33b antibody, Vps 33B antibody, dVps33B antibody, VPS33B antibody, GB11157 antibody, zgc:110803 antibody, Vacuolar protein sorting 33B antibody, VPS33B, late endosome and lysosome associated antibody, vacuolar protein sorting-associated protein 33B antibody, vacuolar protein sorting 33B antibody, Vps33B antibody, VPS33B antibody, LOC551135 antibody, Vps33b antibody, vps33b antibody

Background:

Description: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages (PubMed:18474358). Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes (By similarity).

Gene: VPS33B

Molecular Weight: 71 kDa

Gene ID: 26276

UniProt: Q9H267