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KISS1 antibody (Internal Region)

KISS1 Reactivity: Human, Mouse, Rat WB, IHC, ELISA, ICC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6266238
  • Target See all KISS1 Antibodies
    KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))
    Binding Specificity
    • 7
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    Human, Mouse, Rat
    Host
    • 32
    • 4
    Rabbit
    Clonality
    • 33
    • 3
    Polyclonal
    Conjugate
    • 25
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This KISS1 antibody is un-conjugated
    Application
    • 19
    • 13
    • 9
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificity
    KISS1 Antibody detects endogenous levels of total KISS1.
    Predicted Reactivity
    Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human KISS1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product KISS1 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:20-1:50, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))
    Alternative Name
    KISS1 (KISS1 Products)
    Synonyms
    HH13 antibody, KiSS-1 antibody, metastatin antibody, Eseptin antibody, KiSS-1 metastasis-suppressor antibody, KISS1 antibody, kiss1 antibody, Kiss1 antibody
    Background

    Description: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca2+ levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.

    Gene: KISS1

    Molecular Weight
    15kDa
    Gene ID
    3814
    UniProt
    Q15726
    Pathways
    Positive Regulation of Peptide Hormone Secretion
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