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Integrin alpha 4 (ITGA4) (pSer1027) antibody Primary Antibody

ITGA4 Reactivity: Human, Mouse ELISA, IHC, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6271308
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  • Target
    Integrin alpha 4 (ITGA4)
    Binding Specificity
    pSer1027
    Reactivity
    Human, Mouse
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    Un-conjugated
    Application
    ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
    Specificity
    Integrin α4 (Phospho-Ser1027) Antibody detects endogenous levels of Integrin α4 only when phosphorylated at Ser1027
    Cross-Reactivity
    Human, Mouse (Murine)
    Purification
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogen
    A synthesized peptide derived from human Integrin alpha4 (Phospho-Ser1027)
    Isotype
    IgG
  • Application Notes
    WB 1:1000-3000, IHC 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C.Stable for 12 months from date of receipt
    Expiry Date
    12 months
  • Target
    Integrin alpha 4 (ITGA4)
    Alternative Name
    Integrin alpha4 (ITGA4 Antibody Abstract)
    Synonyms
    CD49D, IA4, LOC100219853, integrin subunit alpha 4, integrin alpha 4, integrin subunit alpha 4 S homeolog, ITGA4, Itga4, itga4.S
    Background

    Description: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877).

    Gene: ITGA4

    Molecular Weight
    115kDa
    Gene ID
    3676
    UniProt
    P13612
    Pathways
    Integrin Complex
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