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Connexin 43/GJA1 antibody (Gap Junction Protein, alpha 1, 43kDa) (pSer282) Primary Antibody

GJA1 Reactivity: Human, Mouse, Rat ELISA, IHC, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6271626
$450.00
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  • Target
    Connexin 43/GJA1 (GJA1)
    Binding Specificity
    • 22
    • 16
    • 15
    • 12
    • 8
    • 8
    • 8
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer282
    Reactivity
    • 140
    • 96
    • 91
    • 35
    • 13
    • 12
    • 10
    • 10
    • 9
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 134
    • 10
    • 10
    Rabbit
    Clonality
    • 142
    • 11
    Polyclonal
    Conjugate
    • 88
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This Connexin 43/GJA1 antibody is un-conjugated
    Application
    • 105
    • 57
    • 52
    • 29
    • 20
    • 18
    • 13
    • 13
    • 10
    • 10
    • 9
    • 6
    • 2
    • 2
    • 1
    ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
    Specificity
    Connexin 43 (Phospho-Ser282) Antibody detects endogenous levels of Connexin 43 only when phosphorylated at Ser282
    Cross-Reactivity
    Human, Mouse (Murine), Rat (Rattus)
    Purification
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogen
    A synthesized peptide derived from human Connexin 43 (Phospho-Ser282)
    Isotype
    IgG
  • Application Notes
    WB 1:1000-3000, IHC 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C.Stable for 12 months from date of receipt
    Expiry Date
    12 months
  • Target
    Connexin 43/GJA1 (GJA1)
    Alternative Name
    Connexin 43 (GJA1 Antibody Abstract)
    Synonyms
    AVSD3, CX43, DFNB38, GJAL, HLHS1, HSS, ODDD, Cx43, AU042049, AW546267, Cnx43, Cx43alpha1, Gja-1, Npm1, connexin43, cx43a1, gja1, zfCx43.3, connexin 43, gja1-A, cx43, gjal, oddd, dfnb38, gap junction protein alpha 1, gap junction protein, alpha 1, connexin 43, gap junction protein alpha 1 L homeolog, CONNEXIN 43 protein, GJA1, Gja1, cx43, gja1.L, gja1, CONNEXIN 43
    Background

    Description: Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity).

    Gene: GJA1

    Molecular Weight
    43kDa
    Gene ID
    2697
    UniProt
    P17302
    Pathways
    MAPK Signaling, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization
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