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RBBP6 antibody (Internal Region)

RBBP6 Reactivity: Human, Mouse WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6279764
  • Target See all RBBP6 Antibodies
    RBBP6 (Retinoblastoma Binding Protein 6 (RBBP6))
    Binding Specificity
    • 15
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 24
    • 24
    • 20
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 35
    • 4
    Rabbit
    Clonality
    • 37
    • 2
    Polyclonal
    Conjugate
    • 21
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RBBP6 antibody is un-conjugated
    Application
    • 32
    • 15
    • 14
    • 14
    • 6
    • 5
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB), ELISA
    Specificity
    RBBP6 Antibody detects endogenous levels of total RBBP6.
    Predicted Reactivity
    Pig,Bovine,Sheep,Rabbit,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human RBBP6, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product RBBP6 Primary Antibody
  • Application Notes
    WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    RBBP6 (Retinoblastoma Binding Protein 6 (RBBP6))
    Alternative Name
    RBBP6 (RBBP6 Products)
    Synonyms
    MY038 antibody, P2P-R antibody, PACT antibody, RBQ-1 antibody, SNAMA antibody, 4933422O15Rik antibody, AI316869 antibody, BB233631 antibody, C030034J04Rik antibody, C77662 antibody, rbbp6 antibody, MGC75882 antibody, RBBP6 antibody, im:7158869 antibody, rbbp6l antibody, RB binding protein 6, ubiquitin ligase antibody, retinoblastoma binding protein 6, ubiquitin ligase antibody, retinoblastoma binding protein 6 antibody, RBBP6 antibody, Rbbp6 antibody, rbbp6 antibody
    Background

    Description: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53, may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).

    Gene: RBBP6

    Molecular Weight
    202 kDa
    Gene ID
    5930
    UniProt
    Q7Z6E9
    Pathways
    Regulatory RNA Pathways
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