AIRE antibody (Ser156)
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- Target See all AIRE Antibodies
- AIRE (Autoimmune Regulator (AIRE))
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Binding Specificity
- AA 100-180, Ser156
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This AIRE antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Purpose
- Rabbit polyclonal to AIRE-1.
- Specificity
- AIRE-1 Polyclonal Antibody detects endogenous levels of AIRE-1 protein.
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Immunogen
- Synthesized peptide derived from human AIRE-1 around the non-phosphorylation site of S156.
- Isotype
- IgG
- Top Product
- Discover our top product AIRE Primary Antibody
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- Application Notes
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WB 1:500-1:2000
ELISA 1:5000 - Comment
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Widely expressed. Expressed at higher level in thymus (medullary epithelial cells and monocyte-dendritic cells), pancreas, adrenal cortex and testis. Expressed at lower level in the spleen, fetal liver and lymph nodes. In secondary lymphoid organs, expressed in a discrete population of bone marrow-derived toleregenic antigen presenting cells (APCs) called extrathymic AIRE expressing cells (eTAC)(at protein level) . Isoform 2 and isoform 3 seem to be less frequently expressed than isoform 1, if at all.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- Target
- AIRE (Autoimmune Regulator (AIRE))
- Alternative Name
- AIRE-1 (AIRE Products)
- Synonyms
- AIRE1 antibody, APECED antibody, APS1 antibody, APSI antibody, PGA1 antibody, autoimmune regulator antibody, autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) antibody, AaeL_AAEL013794 antibody, CpipJ_CPIJ001208 antibody, CpipJ_CPIJ001209 antibody, AIRE antibody, Aire antibody
- Molecular Weight
- 50 kDa
- Gene ID
- 326
- UniProt
- O43918
- Pathways
- Chromatin Binding
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