FZD2 antibody (Internal Region)
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- Target See all FZD2 Antibodies
- FZD2 (Frizzled Family Receptor 2 (FZD2))
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Binding Specificity
- AA 180-260, Internal Region
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This FZD2 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF)
- Purpose
- Frizzled-2 is a protein encoded by the FZD2 gene which is approximately 63,5 kDa. Frizzled-2 is localised to the cell membrane and is involved in CDK-mediated phosphorylation and removal of Cdc6, Wnt signalling pathway and pluripotency and mTOR signalling pathway. It is a receptor for Wnt proteins and is coupled to the beta-catenin canonical signalling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. Frizzled-2 is widely expressed, it is mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. Mutations in the FZD2 gene result in omodysplasia. STJ93141 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Frizzled-2 protein.
- Specificity
- Frizzled-2 Polyclonal Antibody detects endogenous levels of Frizzled-2 protein.
- Characteristics
- Rabbit polyclonal to Frizzled-2.
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Immunogen
- Synthesized peptide derived from human Frizzled-2
- Isotype
- IgG
- Top Product
- Discover our top product FZD2 Primary Antibody
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- Application Notes
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WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:40000 - Comment
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Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal liver.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- Target
- FZD2 (Frizzled Family Receptor 2 (FZD2))
- Alternative Name
- Frizzled-2 (FZD2 Products)
- Synonyms
- BG01711 antibody, CG9739 antibody, D-Fz2 antibody, D-fz2 antibody, DFZ2 antibody, DFz-2 antibody, DFz2 antibody, Dfrz2 antibody, Dfz2 antibody, Dfz[[2]] antibody, Dm Fz2 antibody, Dmel\\CG9739 antibody, FZ2 antibody, Fz2 antibody, dFz2 antibody, dfz(2) antibody, dfz2 antibody, dfz2r antibody, frz2 antibody, fz-2 antibody, fz8 antibody, zfz2 antibody, zg08 antibody, cb383 antibody, wu:fb70g09 antibody, FZD2 antibody, fzE2 antibody, hFz2 antibody, Fz-10 antibody, Fzd10 antibody, cFz-2 antibody, frizzled2 antibody, fz2 antibody, xfz2 antibody, AL033370 antibody, AW456835 antibody, Fz10 antibody, Mfz10 antibody, Mfz10a antibody, frizzled 2 antibody, frizzled class receptor 2 antibody, frizzled class receptor 2 S homeolog antibody, fz2 antibody, fzd2 antibody, FZD2 antibody, Fzd2 antibody, fzd2.S antibody
- Molecular Weight
- 55 kDa
- Gene ID
- 2535
- UniProt
- Q14332
- Pathways
- WNT Signaling
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