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ROCK1 antibody (Internal Region)

ROCK1 Reactivity: Human, Mouse, Rat, Monkey WB, ELISA, IHC (p), ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6287074
  • Target See all ROCK1 Antibodies
    ROCK1 (rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1))
    Binding Specificity
    • 16
    • 16
    • 15
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 78
    • 58
    • 56
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Monkey
    Host
    • 71
    • 8
    Rabbit
    Clonality
    • 58
    • 21
    Polyclonal
    Conjugate
    • 38
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This ROCK1 antibody is un-conjugated
    Application
    • 68
    • 27
    • 26
    • 20
    • 17
    • 15
    • 13
    • 11
    • 11
    • 8
    • 6
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
    Purpose
    Rock-1 is a protein encoded by the ROCK1 gene which is approximately 158,1 kDa. Rock-1 is localised to the cytoplasm, cell membrane and Golgi apparatus membrane. It is involved in blood-brain barrier and immune cell transmigration, development Slit-Robo signalling and activation of cAMP-dependent PKA. It is a serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. Rho regulates formation of focal adhesions and stress fibres of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. It is also involved in the regulation of smooth muscle contraction, actin cytoskeleton organization, stress fibre and focal adhesion formation. Rock-1 is expressed in blood platelets. Mutations in the ROCK1 gene may result in multiple sclerosis and corticobasal degeneration. STJ95527 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Rock-1 protein.
    Specificity
    Rock-1 Polyclonal Antibody detects endogenous levels of Rock-1 protein.
    Characteristics
    Rabbit polyclonal to Rock-1.
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    Immunogen
    Synthesized peptide derived from human Rock-1.
    Isotype
    IgG
    Top Product
    Discover our top product ROCK1 Primary Antibody
  • Application Notes
    WB 1:500-1:2000
    IHC 1:100-1:300
    ICC 1:200-1:1000
    ELISA 1:20000
    Comment

    Detected in blood platelets.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C, and avoid repeat freeze-thaw cycles.
  • Target
    ROCK1 (rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1))
    Alternative Name
    Rock-1 (ROCK1 Products)
    Synonyms
    LOC100229794 antibody, CG9774 antibody, DROK antibody, DRhk antibody, DRok antibody, Dmel\\CG9774 antibody, Drok antibody, ROCK antibody, ROCK-1 antibody, ROCK1 antibody, ROK antibody, ROKalpha/beta antibody, Rhk antibody, RhoK antibody, Rock antibody, Rok antibody, dROK antibody, dRok antibody, drok antibody, 1110055K06Rik antibody, Rock-I antibody, P160Rock antibody, ROCK-I antibody, P160ROCK antibody, p160ROCK antibody, Rho associated coiled-coil containing protein kinase 1 antibody, Rho kinase antibody, Rho-associated coiled-coil containing protein kinase 1 antibody, Rho-associated, coiled-coil containing protein kinase 1 antibody, ROCK1 antibody, Rok antibody, Rock1 antibody, rock1 antibody
    Molecular Weight
    160 kDa
    Gene ID
    6093
    UniProt
    Q13464
    Pathways
    Microtubule Dynamics, WNT Signaling, M Phase, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling
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