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Dual Specificity Phosphatase 3 (DUSP3) antibody

DUSP3 Reactivity: Mouse, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6290308
  • Target See all Dual Specificity Phosphatase 3 (DUSP3) Antibodies
    Dual Specificity Phosphatase 3 (DUSP3)
    Reactivity
    • 41
    • 21
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Mouse, Rat
    Host
    • 52
    • 7
    Rabbit
    Clonality
    • 52
    • 7
    Polyclonal
    Conjugate
    • 27
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Un-conjugated
    Application
    • 41
    • 23
    • 14
    • 13
    • 13
    • 13
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    Affinity purification
    Immunogen
    Recombinant protein of human DUSP3
    Isotype
    IgG
    Top Product
    Discover our top product DUSP3 Primary Antibody
  • Application Notes
    WB 1:500 - 1:1000
    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20C. Avoid freeze / thaw cycles.
  • Target
    Dual Specificity Phosphatase 3 (DUSP3)
    Alternative Name
    DUSP3 (DUSP3 Products)
    Synonyms
    dusp3 antibody, si:bz18k17.3 antibody, si:rp71-18k17.3 antibody, VHR antibody, RGD1560049 antibody, 2210015O03Rik antibody, 5031436O03Rik antibody, T-DSP11 antibody, dual specificity phosphatase 3 antibody, dual specificity phosphatase 3b antibody, dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) antibody, DUSP3 antibody, dusp3b antibody, Dusp3 antibody
    Target Type
    Viral Protein
    Background
    The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.
    Molecular Weight
    20.478 kDa
    Gene ID
    1845
    UniProt
    P51452
    Pathways
    Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
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