PEG3 antibody

Catalog No. ABIN6290778

Product Details anti-PEG3 Antibody

Target: PEG3 (Paternally Expressed 3 (PEG3))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PEG3 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human PEG3

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Comment:

Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus, In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the follicles, Expression is highly repressed in glioma cell lines

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20C. Avoid freeze / thaw cycles.

Target Details for PEG3

Target: PEG3 (Paternally Expressed 3 (PEG3))

Alternative Name: PEG3 (PEG3 Products)

Synonyms: PW1 antibody, ZKSCAN22 antibody, ZNF904 antibody, ZSCAN24 antibody, AL022617 antibody, ASF-1 antibody, End4 antibody, Gcap4 antibody, Pw1 antibody, Zfp102 antibody, mKIAA0287 antibody, PEG3 antibody, paternally expressed 3 antibody, paternally-expressed gene 3 protein antibody, PEG3 antibody, Peg3 antibody, LOC100448879 antibody

Background: In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms.

Molecular Weight: 180.827 kDa

Gene ID: 5178

UniProt: Q9GZU2