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TIM3 antibody

TIM 3 Reactivity: Human, Mouse WB, IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6291690
  • Target See all TIM3 (TIM 3) Antibodies
    TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
    Reactivity
    • 69
    • 34
    • 4
    • 3
    • 2
    • 1
    Human, Mouse
    Host
    • 48
    • 24
    • 23
    • 2
    Rabbit
    Clonality
    • 53
    • 43
    • 1
    Polyclonal
    Conjugate
    • 58
    • 8
    • 7
    • 7
    • 7
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TIM3 antibody is un-conjugated
    Application
    • 43
    • 40
    • 35
    • 23
    • 12
    • 8
    • 5
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Purification
    Affinity purification
    Immunogen
    Recombinant protein of human HAVCR2
    Isotype
    IgG
    Top Product
    Discover our top product TIM 3 Primary Antibody
  • Application Notes
    WB 1:500 - 1:2000
    IHC 1:50 - 1:200
    IF 1:50 - 1:200
    Comment

    Expressed in T-helper type 1 (Th1) lymphocytes, Expressed on regulatory T (Treg) cells after TCR stimulation, Expressed in dendritic cells and natural killer (NK) cells, Expressed in epithelial tissues, Expression is increased on CD4+ and CD8+ T-cells in chronic hepatitis C virus (HCV) infection, In progressive HIV-1 infection, expression is up-regulated on HIV-1-specific CD8 T-cells

    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20C. Avoid freeze / thaw cycles.
  • Target
    TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
    Alternative Name
    HAVCR2 (TIM 3 Products)
    Synonyms
    HAVCR2 antibody, MGC140131 antibody, HAVcr-2 antibody, KIM-3 antibody, TIM3 antibody, TIMD-3 antibody, TIMD3 antibody, Tim-3 antibody, TIM-3 antibody, Tim3 antibody, Timd3 antibody, tim3 antibody, hepatitis A virus cellular receptor 2 antibody, HAVCR2 antibody, Havcr2 antibody
    Target Type
    Virus
    Background
    The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
    Molecular Weight
    33.394 kDa
    Gene ID
    84868
    UniProt
    Q8TDQ0
    Pathways
    Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints
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