CIC antibody

Catalog No. ABIN6292681

Product Details anti-CIC Antibody

Target: CIC (Capicua Homolog (CIC))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CIC antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human CIC

Isotype: IgG

Application Details

Application Notes: WB 1:200 - 1:2000

Comment:

Expressed in fetal brain

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20C. Avoid freeze / thaw cycles.

Target Details for CIC

Target: CIC (Capicua Homolog (CIC))

Alternative Name: CIC (CIC Products)

Synonyms: wu:fb93c01 antibody, CIC antibody, 1200010B10Rik antibody, mKIAA0306 antibody, capicua transcriptional repressor b antibody, capicua transcriptional repressor antibody, cicb antibody, CIC antibody, Cic antibody

Background: The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight: 163.82 kDa

Gene ID: 23152

UniProt: Q96RK0