WWOX antibody

Catalog No. ABIN6293667

Product Details anti-WWOX Antibody

Target: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WWOX antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human WWOX

Isotype: IgG

Application Details

Application Notes: WB 1:1000 - 1:2000

Comment:

Widely expressed, Strongly expressed in testis, prostate, and ovary, Overexpressed in cancer cell lines, Isoform 5 and isoform 6 may only be expressed in tumor cell lines

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20C. Avoid freeze / thaw cycles.

Target Details for WWOX

Target: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Alternative Name: WWOX (WWOX Products)

Synonyms: CG7221 antibody, DmWWOX antibody, Dmel\\CG7221 antibody, anon-EST:Posey177 antibody, GB11795 antibody, WWOX antibody, D16S432E antibody, FOR antibody, FRA16D antibody, HHCMA56 antibody, PRO0128 antibody, SDR41C1 antibody, WOX1 antibody, zgc:55975 antibody, 5330426P09Rik antibody, 9030416C10Rik antibody, WW domain containing oxidoreductase antibody, WW domain-containing oxidoreductase antibody, Wwox antibody, LOC411815 antibody, WWOX antibody, CpipJ_CPIJ004939 antibody, MCYG_01584 antibody, VDBG_05631 antibody, VDBG_01326 antibody, VDBG_06753 antibody, Tsp_03967 antibody, LOC100284583 antibody, wwox antibody

Background: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants.

Molecular Weight: 46.677 kDa

Gene ID: 51741

UniProt: Q9NZC7