PES1 antibody

Catalog No. ABIN6293971

Product Details anti-PES1 Antibody

Target: PES1 (Pescadillo Ribosomal Biogenesis Factor 1 (PES1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PES1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human PES1

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Comment:

Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells, Levels are abnormally elevated in malignant tumors of astrocytic origin

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20C. Avoid freeze / thaw cycles.

Target Details for PES1

Target: PES1 (Pescadillo Ribosomal Biogenesis Factor 1 (PES1))

Alternative Name: PES1 (PES1 Products)

Synonyms: PES antibody, pes antibody, pes1 antibody, pescadillo ribosomal biogenesis factor 1 antibody, pescadillo ribosomal biogenesis factor 1 S homeolog antibody, Pescadillo antibody, PES1 antibody, Pes1 antibody, pes1.S antibody, pesc antibody

Background: This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9.

Molecular Weight: 68.003 kDa

Gene ID: 23481

UniProt: O00541