Proteoglycan 4 antibody

Catalog No. ABIN6294151

Product Details anti-Proteoglycan 4 Antibody

Target: Proteoglycan 4 (PRG4)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Proteoglycan 4 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human PRG4

Isotype: IgG

Application Details

Application Notes: WB 1:200 - 1:2000

Comment:

Highly expressed in synovial tissue, cartilage and liver and weakly in heart and lung, Isoform B is expressed in kidney, lung, liver, heart and brain, Isoform C and isoform D are widely expressed

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20C. Avoid freeze / thaw cycles.

Target Details for Proteoglycan 4

Target: Proteoglycan 4 (PRG4)

Alternative Name: PRG4 (PRG4 Products)

Synonyms: CACP antibody, HAPO antibody, JCAP antibody, MSF antibody, SZP antibody, bG174L6.2 antibody, lubricin antibody, prg4 antibody, si:dkey-97o5.3 antibody, zgc:122988 antibody, PRG4 antibody, DOL54 antibody, proteoglycan 4 antibody, proteoglycan 4b antibody, proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) antibody, PRG4 antibody, Prg4 antibody, prg4b antibody

Background: The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants.

Molecular Weight: 151.077 kDa

Gene ID: 10216

UniProt: Q92954