Insulin antibody (INS)

Details for Product anti-INS Antibody No. ABIN6297593
Antigen
  • ins1
  • xins
  • ins1-a
  • Insulin
  • IDDM2
  • ILPR
  • IRDN
  • MODY10
  • AA986540
  • Ins-2
  • InsII
  • Mody
  • Mody4
  • proinsulin
  • zgc:109842
  • insulin
  • insulin precursor
  • insulin II
  • preproinsulin
  • ins
  • PIN
  • INS
  • Ins
  • INS-IGF2
  • Ins2
Reactivity
Cow (Bovine), Human, Mouse (Murine), Pig (Porcine), Rabbit
722
287
254
235
194
119
11
9
6
6
6
4
3
2
2
2
2
2
1
1
1
1
1
1
Host
Mouse
556
208
48
4
2
1
Clonality
Monoclonal
Conjugate
This Insulin antibody is un-conjugated
39
29
24
15
13
13
8
8
8
8
8
8
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
2
1
Application
Immunohistochemistry (IHC)
338
241
206
168
164
138
106
66
62
36
31
31
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28
21
20
6
5
4
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2
2
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1
1
1
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1
Options
Purpose Mouse anti-Human/Cow/Pig/Rabbit/Mouse Insulin Antibody [IHC only]
Immunogen Recombinant INS protein was used as the immunogen for the Insulin antibody.
Specificity Cytoplasmic
Purification Recombinant INS protein was used as the immunogen for the Insulin antibody.
Plasmids, Primers & others Plasmids, Primers & others Insulin products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Insulin (INS Antibody Abstract)
Background

Target Description: Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.

Gene Symbol: INS

Gene ID 3630
UniProt P01308
Pathways NF-kappaB Signaling, RTK Signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
Application Notes Prediluted format : incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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