Cytochrome C antibody (Cytochrome C, Somatic)

Details for Product anti-CYCS Antibody No. ABIN6297607
Antigen
  • CYC
  • HCS
  • THC4
  • cyct
  • cyc
  • hcs
  • CYCS
  • cytc
  • CYCSA
  • CG17903
  • Cyt C
  • Cyt c
  • Cyt-c2
  • CytC-2
  • Cytc
  • Cytc-p
  • DC4
  • DMc01
  • Dmel\\CG17903
  • cyt c
  • cyt c-p
  • cyt-c-p
  • cyt-c2
  • cyt.c
  • cytochrome c
  • dc4
  • pDMc01
  • wu:fk52b01
  • zgc:86706
  • cytochrome c, somatic
  • cytochrome c, somatic S homeolog
  • Cytochrome c proximal
  • cytochrome c, somatic b
  • cytochrome c-like
  • cytochrome c
  • CYCS
  • cycs.S
  • cycs
  • Cycs
  • Cyt-c-p
  • cycsb
  • LOC100724240
  • CYC
  • LOC100847700
  • LOC101107954
  • LOC106829744
  • LOC106992390
Reactivity
Dog (Canine), Frog, Fruit Fly (Drosophila melanogaster), Horse (Equine), Human, Mouse (Murine), Pigeon, Rat (Rattus)
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270
213
86
62
58
51
44
25
19
13
12
10
8
8
4
2
2
1
1
1
1
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1
1
1
1
1
1
1
Host
Mouse
194
193
8
2
Clonality
Monoclonal
Conjugate
This Cytochrome C antibody is un-conjugated
19
7
6
5
5
5
5
5
5
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
Application
Immunohistochemistry (IHC)
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113
108
107
79
72
46
44
26
25
15
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14
6
4
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1
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Options
Purpose Mouse anti-Human/Mouse/Rat/Horse/Dog/Pigeon/Frog/Drosophila Cytochrome C Antibody [IHC only]
Immunogen Recombinant protein was used as the immunogen for the Cytochrome C antibody.
Specificity Cytoplasmic
Purification Recombinant protein was used as the immunogen for the Cytochrome C antibody.
Plasmids, Primers & others Plasmids, Primers & others Cytochrome C products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Cytochrome c (CYCS Antibody Abstract)
Background

Target Description: Cytochrome C is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3.

Gene Symbol: CYCS///CYC

Gene ID 54205
UniProt P99999
Pathways Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
Application Notes Prediluted format : incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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