Cytochrome C antibody (Cytochrome C, Somatic)

Details for Product anti-CYCS Antibody No. ABIN6297607
Target
Reactivity
Dog, Drosophila melanogaster, Frog, Horse, Human, Mouse, Pigeon, Rat
179
143
121
54
39
33
31
26
15
14
9
8
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7
4
4
2
2
1
1
1
1
1
1
Host
Mouse
106
98
6
2
Clonality
Monoclonal
Conjugate
This Cytochrome C antibody is un-conjugated
16
6
5
4
4
4
4
4
4
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
138
53
51
46
45
35
30
26
16
16
14
11
8
4
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3
3
2
2
1
1
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Options
Purpose Mouse anti-Human/Mouse/Rat/Horse/Dog/Pigeon/Frog/Drosophila Cytochrome C Antibody [IHC only]
Immunogen Recombinant protein was used as the immunogen for the Cytochrome C antibody.
Specificity Cytoplasmic
Purification Recombinant protein was used as the immunogen for the Cytochrome C antibody.
Target
Alternative Name Cytochrome c (CYCS Antibody Abstract)
Background

Target Description: Cytochrome C is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3.

Gene Symbol: CYCS///CYC

Gene ID 54205
UniProt P99999
Pathways Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
Application Notes Prediluted format : incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.