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Target Description: It reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
Gene Symbol: TYRP1///CAS2///TYRP///TYRRP