CD46 Molecule, Complement Regulatory Protein (CD46) antibody

Details for Product No. ABIN6297688
Antigen
  • AHUS2
  • MCP
  • MIC10
  • TLX
  • TRA2.10
  • Mcp
  • CD46 molecule
  • CD46 antigen, complement regulatory protein
  • CD46 molecule, complement regulatory protein
  • membrane cofactor protein-like
  • CD46
  • Cd46
  • LOC100341359
Reactivity
Human
293
50
33
33
26
7
Host
Mouse
221
128
2
Clonality
Monoclonal
Conjugate
Un-conjugated
34
27
23
16
13
8
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF)
218
181
115
73
63
61
33
16
14
10
9
8
8
2
2
1
Options
Purpose Mouse anti-Human CD46 Antibody [Sodium Azide Free]
Immunogen Stimulated human leukocytes were used as the immunogen for the CD46 antibody.
Specificity Cell surface
Purification Stimulated human leukocytes were used as the immunogen for the CD46 antibody.
Antigen
Alternative Name Membrane cofactor protein (CD46 Antibody Abstract)
Background

Target Description: Recognizes a protein of 52 kDa-58 kDa, identified as CD46 (also known as membrane cofactor protein, MCP). CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria. This mAb can be applied to test complement activation in pseudo-allergic reactions to acetylsalicylic acid and to test for measles virus infection of cells.

Gene Symbol: CD46///MCP///MIC10

Gene ID 4179
UniProt P15529
Pathways Regulation of Actin Filament Polymerization
Application Notes Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Restrictions For Research Use only
Buffer In 1X PBS, BSA free, sodium azide free
Preservative Azide free
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.